DCC : DCC netrin 1 receptor

The DCC Gene and Its Role in the Nervous System

Description

The DCC (Deleted in Colorectal Cancer) gene is responsible for producing netrin-1 receptor, a crucial protein that guides the development of the nervous system. This receptor consists of three key parts:

• Extracellular region: Projects from the cell surface and binds to a molecule called netrin-1.
• Transmembrane region: Anchors the receptor to the cell membrane.
• Intracellular region: Transmits signals to the cell‘s interior.

Role in Nervous System Development

The netrin-1 receptor binds to netrin-1, which helps direct the growth of axons, specialized nerve cell extensions that transmit nerve impulses. These impulses control muscle movement, ensuring that signals from each brain hemisphere control muscles on the opposite side of the body. By preventing axons from developing abnormally, the netrin-1 receptor helps maintain proper neural connectivity.

Dependence Receptor Function

Uniquely, the netrin-1 receptor acts as a dependence receptor, exhibiting different functions with and without its ligand. When bound to netrin-1, it triggers signaling related to nervous system development. However, when not bound to netrin-1, it acts as a tumor suppressor, preventing uncontrolled cell growth and division. Studies suggest that without netrin-1 binding, the receptor induces programmed cell death (apoptosis).

Associated Diseases

Mutations in the DCC gene have been linked to several disorders, including:

• Colorectal cancer
• Gastric cancer
• Ovarian cancer
• Brain tumors

Did you Know ?

According to a study published in the journal Nature Genetics, mutations in the DCC gene are found in approximately 10% of colorectal cancer cases.