CTGF

Description

The CTGF (Connective Tissue Growth Factor) gene plays a crucial role in regulating tissue development, repair, and fibrosis. It encodes a protein that acts as a signaling molecule, promoting cell proliferation, migration, and extracellular matrix production. CTGF is involved in various biological processes, including wound healing, angiogenesis, and organ development. Its expression is tightly regulated by growth factors, cytokines, and mechanical stress. Dysregulation of CTGF expression can contribute to the development of fibrotic diseases, cancer, and other pathological conditions.

Associated Diseases

• Fibrosis (liver, kidney, lung, heart)
• Cancer (breast, prostate, lung, colon)
• Scleroderma
• Diabetic nephropathy
• Wound healing disorders

Did you know?

CTGF was originally discovered as a growth factor for connective tissue cells, but it has since been found to have a broader range of functions in various cell types and tissues.