CPA6
Description
The CPA6 (carboxypeptidase A6) is a protein-coding gene located on chromosome 8.
CPA6 is a metallocarboxypeptidase enzyme encoded by the CPA6 gene in humans. It is highly expressed in the adult mouse olfactory bulb and has broad expression in the embryonic brain and other tissues. CPA6 belongs to the carboxypeptidase family, which catalyzes the release of C-terminal amino acids and has diverse functions, including food digestion and selective biosynthesis of neuroendocrine peptides. Variations in CPA6, including polymorphic variants and a reciprocal translocation t(6;8)(q26;q13), have been linked to Duane retraction syndrome. CPA6 processes several neuropeptides in vitro, including [Met]- and [Leu]-enkephalin, angiotensin I, and neurotensin. While CPA6 can inactivate enkephalins and neurotensin, it activates angiotensin I by converting it into angiotensin II. Although CPA6 likely has additional roles in processing peptides and proteins in vivo, the specific substrates and effects of these cleavages remain unknown.
CPA6 is a metallocarboxypeptidase enzyme that removes the C-terminal amino acid from peptides and proteins. It exhibits a preference for large hydrophobic C-terminal amino acids and shows limited activity towards small amino acids and histidine. CPA6 plays a role in the regulation of neuropeptide activity by inactivating enkephalins and neurotensin in certain brain regions. However, it also contributes to the activation of angiotensin I, converting it into the biologically active angiotensin II.
CPA6 is also known as CPAH, ETL5, FEB11.
