CLPB : ClpB family mitochondrial disaggregase

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Description

The CLPB gene encodes a protein known as ClpB, a molecular chaperone vital for maintaining cellular homeostasis. ClpB belongs to the Hsp100 family of heat shock proteins and functions in protein disaggregation, a crucial process for rescuing misfolded or aggregated proteins that can disrupt cellular processes. This protein works in concert with other chaperones like DnaK and DnaJ, forming a complex machinery that refolds misfolded proteins and removes damaged ones, thereby preventing cellular stress and dysfunction.

Associated Diseases

• Neurodegenerative diseases (Alzheimer‘s, Parkinson‘s, Huntington‘s)
• Cancer
• Infectious diseases
• Aging

Did you know?

ClpB is found in bacteria, archaea, and eukaryotes, highlighting its fundamental role in cellular survival across diverse life forms.