CLDN14
Description
The CLDN14 (claudin 14) is a protein-coding gene located on chromosome 21.
CLDN14 is a gene that codes for a protein called Claudin-14. This protein is essential for forming tight junctions, which act as barriers between cells in tissues like the skin, gut, and blood vessels. Tight junctions prevent unwanted substances from passing through these tissues. CLDN14 defects are linked to hearing loss, and the protein also seems to play a role in blood vessel formation. Variations in CLDN14 are associated with an increased risk of kidney stones.
CLDN14 is also known as DFNB29.
