CLDN10
Description
The CLDN10 (claudin 10) is a protein-coding gene located on chromosome 13.
Claudin-10 is a protein encoded by the CLDN10 gene in humans. It belongs to the claudin family, which are integral membrane proteins involved in forming tight junctions. These junctions act as barriers, preventing the free passage of solutes and water between epithelial or endothelial cells. Two isoforms of Claudin-10, generated by alternative splicing, have been identified.
Claudin-10 plays a crucial role in creating tight junctions between cells, effectively sealing off the spaces between them. This is achieved through calcium-independent cell-adhesion activity. Claudin-10 also contributes to the regulation of ion permeability across epithelial layers in various organs. It acts as a paracellular ion channel, forming pores that allow specific ions to pass through. Isoform 1 is thought to create pores that are preferentially permeable to cations, while isoform 2 favors anions. Notably, in sweat glands and the thick ascending limb of Henle's loop in the kidney, Claudin-10 controls sodium permeability, which is vital for proper sweat production and renal function.
CLDN10 is also known as CPETRL3, HELIX, OSP-L, OSPL.
