CHST11
Description
The CHST11 (carbohydrate sulfotransferase 11) is a protein-coding gene located on chromosome 12.
The CHST11 gene encodes for Carbohydrate sulfotransferase 11, an enzyme involved in human biology. Mutations in this gene are linked to an increased susceptibility for osteoarthritis. The gene's location and details can be found on the UCSC Genome Browser.
CHST11 catalyzes the addition of a sulfate group to the 4th position of N-acetylgalactosamine (GalNAc) within the chondroitin molecule. This sulfation is crucial for the formation of chondroitin sulfate, a primary proteoglycan in cartilage that also plays a role in the structure of various cell surfaces and extracellular matrices. CHST11 exhibits the capability to sulfate Gal residues found in desulfated dermatan sulfate. Furthermore, it demonstrates a preference for sulfating GlcA->GalNAc units over IdoA->GalNAc units. Importantly, CHST11 does not produce 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as the substrate.
CHST11 is also known as C4ST, C4ST-1, C4ST1, HSA269537, OCBMD.
