CES1
Description
The CES1 gene encodes for carboxylesterase 1, an enzyme primarily found in the liver that plays a crucial role in detoxification. It breaks down various compounds, including drugs, toxins, and environmental pollutants, into less harmful substances that can be excreted from the body. This process is essential for maintaining overall health and preventing the accumulation of toxic substances. CES1 also participates in lipid metabolism and the synthesis of certain neurotransmitters.
Associated Diseases
- **Organophosphate poisoning:** CES1 is involved in the breakdown of organophosphates, commonly used in pesticides. Mutations in CES1 can lead to increased susceptibility to organophosphate poisoning.
- **Drug metabolism:** Variations in CES1 activity can affect the metabolism of certain drugs, potentially impacting their effectiveness or causing adverse reactions.
- **Cancer:** Some studies suggest a link between CES1 gene variants and cancer risk, particularly in the liver and other organs.
- **Neurological disorders:** CES1 is involved in the production of neurotransmitters, and variations in its activity may be associated with neurodevelopmental disorders.
Did you know?
The CES1 gene is highly polymorphic, meaning it exhibits many variations in its DNA sequence, leading to different enzyme activity levels among individuals.
