CEP250
Description
The CEP250 (centrosomal protein 250) is a protein-coding gene located on chromosome 20.
CEP250 is a core centrosomal protein encoded by the CEP250 gene. It is essential for centriole-centriole cohesion during interphase of the cell cycle. CEP250 detaches from the centrosomes when centrioles separate at the beginning of mitosis. It interacts with and is phosphorylated by NIMA-related kinase 2 (Nek2), another centrosomal protein. Additionally, CEP135 is required for the localization of CEP250 to the centrioles.
CEP250 may play a role in ciliogenesis, and is likely important for maintaining centrosome cohesion during interphase. It also recruits CCDC102B to the proximal ends of centrioles.
CEP250 is also known as C-NAP1, CEP2, CNAP1, CRDHL2.
