CEP135
Description
The CEP135 (centrosomal protein 135) is a protein-coding gene located on chromosome 4.
CEP135 is a protein encoded by the CEP135 gene in humans. It is found in the centrosome throughout the cell cycle and is located in the pericentriolar material. CEP135 is necessary for the localization of CEP250 to the centriole.
CEP135 is a centrosomal microtubule-binding protein involved in centriole biogenesis. It acts as a scaffolding protein during early centriole biogenesis and is required for the targeting of centriole satellite proteins such as PCM1, SSX2IP and CEP290 to centrosomes and the recruitment of WRAP73 to centrioles. CEP135 is also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. During early S phase, CEP135 is required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall in a PLK4-dependent manner.
CEP135 is also known as CEP4, KIAA0635, MCPH8.
