CDH3

Description

CDH3, also known as P-cadherin, is a gene that encodes a cell adhesion protein crucial for maintaining cell-cell interactions, particularly in epithelial tissues. This protein plays a vital role in tissue development, organization, and function. CDH3 is expressed in various tissues, including the placenta, skin, and mammary glands. Its primary function is to facilitate cell-to-cell connections, ensuring proper tissue structure and integrity. Mutations or dysregulation of CDH3 can disrupt these interactions, contributing to the development of various diseases.

Associated Diseases

• Invasive Lobular Breast Cancer (ILC)
• Endometriosis
• Ovarian Cancer
• Gastric Cancer
• Colorectal Cancer
• Melanoma
• Neuroblastoma
• Hereditary Diffuse Gastric Cancer (HDGC)

Did you know?

CDH3 gene expression is influenced by estrogen, suggesting a potential link between CDH3 and hormone-dependent cancers.