CD70
Description
The CD70 (CD70 molecule) is a protein-coding gene located on chromosome 19.
CD70 (Cluster of Differentiation 70) is a protein encoded by the CD70 gene in humans. It functions as a ligand for CD27. CD70 expression on immune cells is tightly controlled and typically occurs transiently. It's primarily found on highly activated T cells, B cells, NK cells, and mature dendritic cells. Its expression on T and B cells is triggered by activation of their respective receptors and can be influenced by cytokines such as IL-1α, IL-2, IL-12, GM-CSF, and TNF-α, with IL-4 and IL-10 having the opposite effect. CD70 expression on mDCs and pDCs is induced by Toll-like receptor (TLR) triggering and CD40 ligation. Furthermore, CD70 can be induced on NK cells upon stimulation with IL-15. CD70 serves as a costimulatory molecule, playing a critical role in regulating immune system activation. It enhances T-cell and B-cell activation, proliferation, and survival, resulting in a more robust immune response. CD70 on activated antigen presenting cells (APCs), including dendritic cells and B cells, binds to CD27 on T lymphocytes, providing costimulatory signals. The interaction between CD27 and CD70 leads to the recruitment of intracellular adaptor proteins, such as TRAF2 and TRAF5, which then activate signaling pathways, including the NF-κB and JNK pathway.
CD70 is a cytokine that acts as the ligand for CD27. The CD70-CD27 pathway is crucial for generating and maintaining T cell immunity, particularly during antiviral responses. When CD27 binds to CD70, it triggers proliferation of costimulated T-cells and boosts the production of cytolytic T-cells.
CD70 is also known as CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A.
