CD320
Description
The CD320 (CD320 molecule) is a protein-coding gene located on chromosome 19.
CD320 (cluster of differentiation 320) is a human gene.
CD320 is a receptor for transcobalamin saturated with cobalamin (TCbl), playing a crucial role in cobalamin uptake. It is a plasma membrane protein expressed on follicular dendritic cells (FDCs), mediating interactions with germinal center B cells. CD320 acts as a costimulator, enhancing B cell responses to antigenic stimuli and promoting B cell differentiation and proliferation. It is involved in the differentiation of germinal center B cells into memory B-cells and plasma cells through interactions with T-cells and FDCs. Additionally, CD320 enhances the proliferation of plasma cell precursors generated by IL-10.
CD320 is also known as 8D6, 8D6A, TCBLR, TCII-R, TCN2R, sCD320.
