CCNO
Description
The CCNO (cyclin O) is a protein-coding gene located on chromosome 5.
Cyclin-O is a protein encoded by the CCNO gene in humans. It has been shown to interact with RPA2 and PCNA. CCNO's role is related to the development of multiciliated cells, likely by promoting a cell cycle state compatible with centriole amplification and maturation. It operates downstream of MCIDAS, promoting mother centriole amplification and maturation in preparation for apical docking.
CCNO plays a crucial role in the development of multiciliated cells. It likely achieves this by facilitating a specific cell cycle stage that allows for the amplification and maturation of centrioles. Acting downstream of MCIDAS, CCNO promotes the amplification and maturation of mother centrioles, ultimately preparing them for docking at the apical region of the cell.
CCNO is also known as CCNU, CILD29, UDG2.
