CAMK2A
Description
The CAMK2A gene encodes a calcium/calmodulin-dependent protein kinase II alpha, a crucial enzyme involved in regulating synaptic plasticity, learning, and memory. CAMK2A plays a pivotal role in the phosphorylation of various substrates within the postsynaptic density, including AMPA receptors. This phosphorylation modulates the strength of synaptic connections, contributing to the formation and consolidation of long-term memories. CAMK2A is highly expressed in the brain, particularly in the hippocampus and cortex, regions critical for learning and memory.
Associated Diseases
Did you know?
CAMK2A is a highly abundant protein in the brain, comprising about 1-2% of total brain protein.
