C5

Description

The C5 gene encodes the fifth component of the complement system, a crucial part of the innate immune system. The complement system is a cascade of proteins that works to identify and destroy pathogens, such as bacteria and viruses. C5 plays a central role in this process, acting as a bridge between the early and late stages of the cascade. It‘s involved in the formation of the membrane attack complex (MAC), which directly punctures the membrane of pathogens, leading to their destruction.

Associated Diseases

• Paroxysmal nocturnal hemoglobinuria (PNH)
• Atypical hemolytic uremic syndrome (aHUS)
• Hereditary angioedema (HAE)
• Systemic lupus erythematosus (SLE)
• Immune complex-mediated diseases

Did you know?

C5 deficiency is a rare genetic disorder that leaves individuals more susceptible to certain infections due to a weakened complement system.