BIN1 : bridging integrator 1

Description

The BIN1 gene, located on chromosome 11, encodes a protein known as bridging integrator 1 (BIN1). This protein plays a crucial role in various cellular processes, including endocytosis, vesicle trafficking, and the regulation of actin cytoskeleton dynamics. BIN1 interacts with a wide range of proteins, influencing membrane trafficking pathways and contributing to cellular signaling events. Its expression patterns and functional diversity have linked BIN1 to multiple biological processes and diseases.

Associated Diseases

• Alzheimer‘s disease
• Amyotrophic lateral sclerosis (ALS)
• Parkinson‘s disease
• Charcot-Marie-Tooth disease
• Spinocerebellar ataxia
• Cancer (e.g., breast cancer, prostate cancer)

Did you know?

BIN1 gene variants have been linked to the formation of amyloid plaques in the brain, a hallmark of Alzheimer‘s disease.