AURKC : aurora kinase C
Description
The AURKC (aurora kinase C) is a protein-coding gene located on chromosome 19.
The AURKC gene provides instructions for producing aurora kinase C, a protein that regulates essential events during cell division. This protein helps separate dividing cells and ensures each new cell receives a complete set of chromosomes. Aurora kinase C is most abundant in the testes, where it regulates the division of sperm cells, ensuring each new sperm cell divides correctly and contains one copy of each chromosome.
Aurora kinase C (AURKC) is a key component of the chromosomal passenger complex (CPC), which plays a critical role in regulating mitosis. The CPC ensures accurate chromosome segregation during cell division by controlling chromosome alignment and microtubule stability. AURKC also participates in meiosis, particularly in spermatogenesis. It can compensate for the loss of AURKB, suggesting functional redundancy. Like AURKB, AURKC modifies histone H3 by phosphorylation at specific residues, enhancing its own activity. It also phosphorylates other CPC subunits, including BIRC5/survivin and INCENP, as well as TACC1, another protein involved in cell division.
AURKC is also known as AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C.
