ATIC
Description
The ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) is a protein-coding gene located on chromosome 2.
ATIC can refer to the human gene ATIC, which encodes a bifunctional protein involved in purine biosynthesis and insulin signaling.
ATIC is a bifunctional enzyme that catalyzes the final two steps of purine biosynthesis. ATIC acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). ATIC can utilize both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. ATIC also catalyzes the cyclization of FAICAR to IMP. ATIC is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. ATIC promotes insulin receptor (INSR) autophosphorylation and is involved in INSR internalization.
ATIC is also known as AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH.
