AP1B1
Description
The AP1B1 (adaptor related protein complex 1 subunit beta 1) is a protein-coding gene located on chromosome 22.
AP-1 complex subunit beta-1 (AP1B1) is a protein encoded by the AP1B1 gene in humans. It is a component of the adaptor protein complex 1 (AP-1), which is located on the cytoplasmic face of coated vesicles at the Golgi complex. AP-1 mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer consisting of two large, one medium, and one small adaptin subunit. AP1B1 serves as one of the large subunits of this complex and belongs to the adaptin protein family. The AP1B1 gene is considered a candidate meningioma gene. Two transcript variants encoding different isoforms have been identified for this gene, along with variants utilizing alternative polyadenylation signals. AP1B1 has been shown to interact with KIF13A and AP1G1.
AP1B1, a subunit of the clathrin-associated adaptor protein complex 1 (AP-1), plays a crucial role in sorting proteins within the late-Golgi/trans-Golgi network (TGN) and/or endosomes. AP complexes, like AP-1, are responsible for recruiting clathrin to membranes and recognizing sorting signals within the cytosolic tails of transmembrane cargo molecules.
AP1B1 is also known as ADTB1, AP105A, BAM22, CLAPB2, KIDAR.
