ALS2 : alsin Rho guanine nucleotide exchange factor ALS2


Description

The ALS2 (alsin Rho guanine nucleotide exchange factor ALS2) is a protein-coding gene located on chromosome 2.

The ALS2 gene instructs the production of alsin, a protein found in various tissues, notably in motor neurons. Alsin activates GTPases, which are involved in vital cellular processes like cell division, differentiation, and apoptosis. These GTPases are essential for the proper arrangement of cell membrane components, the transport of molecules into the cell (endocytosis), and the development of axons and dendrites, crucial structures for nerve impulse transmission.

Alsin regulates the activity of GTPases, which are essential for various cellular processes including cell division, differentiation, and programmed cell death. Alsin is particularly crucial for the survival and growth of spinal motoneurons.

ALS2 is also known as ALS2CR6, ALSJ, IAHSP, PLSJ.

Associated Diseases


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