ALKBH8
Description
The ALKBH8 (alkB homolog 8, tRNA methyltransferase) is a protein-coding gene located on chromosome 11.
ALKBH8 (also known as ABH8, Trm9, or tRNA methyltransferase 9) is an enzyme that catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine in tRNA.
ALKBH8 is a tRNA methyltransferase that catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. This reaction is the last step in the formation of 5-methylcarboxymethyl uridine. ALKBH8 has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). ALKBH8 also acts as a dioxygenase, catalyzing the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine to 5-(S)-methoxycarbonylhydroxymethyluridine. This reaction has a preference for tRNA(Gly). ALKBH8 is required for normal survival after DNA damage and may inhibit apoptosis and promote cell survival and angiogenesis.
ALKBH8 is also known as ABH8, MRT71, TRM9, TRMT9, TRMT9A.
