AIRE : autoimmune regulator


Description

The AIRE gene, short for Autoimmune Regulator, plays a critical role in maintaining immune tolerance by expressing tissue-specific antigens in the thymus. This process, known as ‘negative selection,‘ eliminates self-reactive T cells that could attack the body‘s own tissues. Mutations in the AIRE gene can lead to a range of autoimmune disorders.

Associated Diseases

Did you know?

AIRE acts like a master switch, turning on the expression of hundreds of tissue-specific genes in the thymus, creating a diverse array of self-antigens for immune system training.


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