ADCY3

Description

The ADCY3 gene encodes adenylate cyclase type 3, an enzyme crucial for cellular signaling. It catalyzes the conversion of ATP to cyclic AMP (cAMP), a secondary messenger involved in diverse cellular processes including cell growth, differentiation, and neurotransmission. ADCY3 is expressed in various tissues, particularly in the brain, heart, and skeletal muscle. Its activity is regulated by various factors, including G protein-coupled receptors (GPCRs) and calcium. Mutations in ADCY3 have been linked to various neurological and developmental disorders.

Associated Diseases

• Schizophrenia
• Bipolar disorder
• Autism spectrum disorder
• Attention-deficit/hyperactivity disorder (ADHD)
• Intellectual disability
• Epilepsy
• Parkinson‘s disease

Did you know?

ADCY3 is a highly polymorphic gene, meaning there are many variations in its sequence among individuals. Some of these variations have been associated with altered risk for certain diseases.