ABHD12

ABHD12: A Key Enzyme in Lipid Metabolism and Health

Description:

ABHD12 (Abhydrolase Domain Containing 12) is an enzyme involved in lipid metabolism, particularly in the breakdown of endocannabinoids, a group of lipid signaling molecules known for their role in pain, appetite, and mood regulation. It is primarily located in the liver and brain, where it plays a crucial role in regulating endocannabinoid activity.

Associated Diseases:

ABHD12 dysfunction has been linked to various diseases and conditions, including:

• Obesity: Studies have shown that individuals with elevated ABHD12 levels have increased body weight and fat mass.
• Metabolic syndrome: ABHD12 deficiency has been associated with impaired glucose and lipid metabolism, leading to an increased risk of metabolic syndrome.
• Neurodegenerative disorders: Reduced ABHD12 activity has been implicated in Alzheimer‘s disease and Parkinson‘s disease, suggesting a role in neuroinflammation and neuronal protection.

Did you Know ?

A recent study found that individuals with a genetic variant that increases ABHD12 activity have a 15% higher risk of developing obesity. This highlights the significant impact of ABHD12 on weight regulation.