ABCG8 : ATP binding cassette subfamily G member 8

Sterolin: The Gatekeeper of Dietary Fats

Description

Sterolin is a protein that plays a crucial role in regulating the levels of plant sterols and cholesterol in the human body. Plant sterols are fatty components found in plant-based foods that cannot be used by human cells. Cholesterol, on the other hand, is a fatty substance found in animal products and the human body itself.

The sterolin protein is made up of two subunits: sterolin-1 and sterolin-2. The genes responsible for producing these subunits are called ABCG5 and ABCG8, respectively. Sterolin functions as a transporter protein, which means it moves substances across cell membranes.

Associated Diseases

Mutations in the ABCG5 or ABCG8 genes can lead to disorders in sterolin production or function, resulting in the following diseases:

• Sitosterolemia: An inherited disorder characterized by high levels of plant sterols in the blood and tissues, leading to premature cardiovascular disease and liver damage.
• Cholestasis: A condition in which bile flow is obstructed, causing a buildup of bile and other substances in the liver.

Did you Know ?

Only about 5% of dietary plant sterols are absorbed into the bloodstream, thanks to the efficient work of sterolin transporters in the intestines and liver.